A loxP site and Frt-floxed neo cassette were inserted in intron 1, with F3-flanked puromycin cassette followed by second loxP site in intron 6. Cre-mediated recombination removed exons 2-6, neomycin and puromycin cassettes. (J:223817)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count