A loxP site was inserted upstream of exon 4 and a FRT-flanked neomycin cassette with a 3' loxP site were inserted downstream of exon 5. Flp-mediated recombination removed the neo cassette leaving exons 4 and 5 floxed. (J:225609)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count