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EN
The murine mutant delta subunit of the acetylcholine receptor which has a threonine for serine substitution at position 262 (S262T) of the second transmembrane domain is under the control of the mouse creatine kinase muscle promoter. A neomycin resistance gene was also inserted downstream of the Chrnd cDNA. Four lines were established: 18, 22, 31, and 40. Line 40 has a transgene copy number of about 25 and is the medium expressing line. (J:31221)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
