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A loxP site was inserted into exon 22 downstream of the STOP codon. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted into exon 22 downstream of the 1.1 kb sequence to be deleted from the 3' UTR, followed by three SV40 polyA signals. Flp-mediated recombination removed the selection cassette and cre-mediated recombination deleted the 1.1 kb sequence in the 3' UTR. RT-PCR confirmed the absence of transcripts with an intact 3' UTR. (J:222342)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
