Flp-mediated excision of the parental Bbs5tm1a(EUCOMM)Wtsi allele resulted in the removal of the promoter-driven neomycin selection cassette and the inserted lacZ reporter sequence, leaving behind the loxP-flanked critical exons 4-5. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739, J:307098)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count