A loxP site was inserted upstream of exon 1 and a FRT flanked neomycin positive selection gene and a loxP site were inserted downstream of exon 1 by homologous recombination. Flp-mediated recombination removed the neo cassette leaving exon 1 flanked by loxP sites. (J:224701)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count