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The chicken beta-globin insulator sequence and tetracycline operator are used to drive inducible expression of a constitutively active human PTPN11 containing the E76K mutation with a C-terminal Flag tag. A pair of oppositely oriented heterotypic L3 and L2 loxP sites flank the transgenic cassette. Three lines that show no leaky expression of the transgene were created: 398, 425, and 417. However, the pound symbol (#) is used when the line is not specified and/or lines are pooled. (J:212505)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
