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A TGTCGG to GCCAGA mutation at nucleotides 168-173 of exon 11 encoding a C472A substitution was introduced and an FRT flanked neo cassette was inserted in intron 10 via homologous recombination. Flp mediated recombination removed the neo cassette. Immunoblot analysis indicates expression of the mutant protein at levels similar to wild-type protein. The C472A mutation produces a catalytically inactive protein that fails to cleave multiple substrates (Bcl-10, Regnase-1, RelB, and CYLD). (J:216675)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
