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The human BCL2 with amino acids 101-103 mutated from glycine-aspartate-aspartate to alanine-alanine-alanine to abolish BH3 domain pro-apoptotic function is under the control of the T cell-specific Cd4 locus control region (LCR). Immunohistochemistry confirmed expression of the transgene in thymocytes. A compensatory downregulation of endogenous mouse Bcl2 in the thymus, lymph nodes, and spleen is seen with transgene expression. Two lines were chosen for analysis, A and B, with similar phenotypes. (J:217939)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
