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R3A and K5A mutations were inserted in exon 1 and a floxed neo cassette was inserted into intron 1 via homologous recombination. The mutation in exon 1 disrupts interaction of the protein with subunits of the nucleosome remodeling and histone deacetylase complex. Cre mediated recombination removed the neo cassette. Western blot analysis of E13.5 heart lysates revealed comparable protein levels in wild-type, heterozygous, and homozygous mutant hearts. (J:216295)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
