A genomic region spanning the entire open reading frame (exons 2-6) was replaced with a construct including an NLS-lacZ, viral T2A sequence, histone 2B, Venus reporter gene, and SV40-pA and a floxed neo cassette via homologous recombination. Cre mediated recombination removed the neo cassette. (J:215971)
Basic Information
(C57BL/6J x 129S6/SvEvTac)F1
Insertion, Intragenic deletion
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count