A loxP site was inserted upstream of exon 1 and a loxP site and an FRT flanked neo cassette were inserted downstream of exon 1 via homologous recombination. Cre mediated recombination removed exon 1. (J:180017)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count