This allele from project Wdr17-6900-M282 was generated at The Jackson Laboratory by injecting Cas9 RNA and 3 guides sequences, TTAGTTAATCACACCTTCGA, CGTTCCAAATGATCACTAAG and AACAGTTGAGTTCTTCTTTT, which resulted in a 159 bp deletion beginning in intron 4 at Chromosome 8 negative strand position 54,693,261 bp starting at GTTGGGCATGCTTTGTTTTAG and ending after TAACTTAGTGATCATTTGG at position 54,693,103 bp in exon 4 (GRCm38). This mutation removes 21 bp from intron 4 and 138bp from exon 4 essentially deleting exon 4 from the transcript, and is predicted to cause an amino acid change after residue 65 and early truncation 141 amino acids later. (J:188991)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NJ
Endonuclease-mediated
Intragenic deletion
Not Specified
1
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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