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A lacZ gene with a nuclear localization signal (nls-lacZ) was placed under the control of the TP1 promoter, which consists of 12 multimerized RBP-Jkappa binding motifs upstream from a minimal beta-globin promoter. The TP1 promoter is transactivated in a RBP-Jkappa-dependent manner by the activated forms of the four mammalian Notch receptors, and can be used to detect Notch pathway activity. Only one transgenic line generated was shown to express lacZ and was expanded and studied further. (J:110140)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
