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The transgene contains the zinc-inducible mouse metallothionein I promoter sequences upstream of the hepatitis B virus HBsAg coding region. The HBsAg coding region is the 2.3 kbp BglII A fragment from the hepatitis B virus genome spanning nucleotides 2839 and 1986 (from GenBank V01460.1). This region contains the entire HBV envelope/surface antigen (HBsAg) open reading frame (pre-S1, pre-S1 and S), the region between the S and X genes, and the X gene. The HBV large envelope protein is produced only from a larger transcript emanating from the transcription start sites defined by the mouse metallothionein I promoter, but the middle and small envelope proteins are regulated by a constitutively active internal promoter located within the envelope coding region. (J:139865)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
