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The rtTA2S-M2 variant is expressed under the control of the hnRNPA2/B1 promoter. An ~8 kb DNA fragment was used that encompasses the human hnRNPA2/B1-CBX3 gene locus CpG island, which includes two divergently transcribed promoters. Seven transgenic lines were established through transmission of the transgene. Transgenic founder 2 had two integration sites, which separated upon breeding to generate lines 2a and 2b. Line 9 is the highest expressing line in all tissues tested, lines 2a and 2b expressed weakly in some tissues, whereas lines 1, 4, 6 and 7 expressed low but detectable levels. Line 9 was expanded and studied further. (J:128742)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
