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The transgenic construct contained the entire mouse Cnp promoter region coupled to the 800-bp quail cDNA encoding the glycosylphosphatidylinositol-linked form of TVA (CD320 or Tv-a) gene, the receptor for avian retrovirus ALV, subgroup A (ALV-A), followed by an IRES (internal ribosomal entry site) sequence and the lacZ gene. Pronuclear injection generated three chimera founders with germ-line transmission (A7, B8 and C16). After initial characterization for expression of TVA the B8 line was selected for further breeding. (J:151346)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
