A loxP site was inserted upstream of exon 5 and an frt-flanked neo cassette was inserted after exon 6, followed by another loxP site. RT-PCR analysis indicates that homozygotes contain only 35% of wild-type Tfap2a levels and RNA analysis indicates that the allele generates aberrant transcripts. (J:88826)
Basic Information
129S1/Sv-Oca2+ Tyr+ Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count