Tg(CMV-ATXN3*135Q)CPama

The human ATXN3c cDNA variant carrying a repeat tract with the sequence (CAG)2CAAAAGCAGCAA(CAG)129, coding for 135 glutamines, is under the regulation of the CMV promoter. This line has two copies of the transgene and expresses the human mRNA at near-endogenous levels in the cerebellum, brainstem, forebrain and spinal cord. With breeding, mice show intergenerational CAG repeat length variation, mostly towards contraction. (J:222991)