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The cDNA encoding human KCNIP3 (DREAM) with two amino-acid substitutions each at EFhands 2, 3 and 4 (EFmDREAM) was inserted downstream of the human CaMKII promoter. The cDNA was followed by an IRES and the LacZ reporter gene. The amino acid substitutions rendered the mutant insensitive to Ca2+, and thus can block the Ca2+dependent derepression function of DREAM and other KChIP proteins endogenously expressed. (J:103733)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
