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Exons 1-13 along with a 2-kb upstream region were replaced with a R4 integrase attB- and attP- flanked neomycin cassette. The neomycin cassette was then removed by transient expression of R4 integrase in the targeted clones. RT-PCR analysis confirmed absence of mRNA expression in E10.5 homozygous mutant embryos and yolk-sac tissues. (J:215242)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
