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Six consecutive c-myc epitopes were introduced after the signal sequence of rat GluR6 (Grik2) cDNA. This construct was expressed by an 8.5 kB Ca2+-calmodulin-dependent protein kinase II (CaMKIIalpha) promoter. Six lines were created, including 23, 26 and 28. Differing genomic integration positions generated mouse lines with a variable pattern of expression of the transgene. In line 28, the construct was evenly expressed in the hippocampus, the neocortex, and the striatum, whereas in others, the expression was more abundant in a particular brain region (neocortex for line 23, hippocampus for line 26). Line 28 was expanded for further study. (J:78109)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
