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The 5' untranslated region (5'-UTR) of the gene is interrupted 1,046 base pairs downstream of the transcription start site by a splice acceptor followed by a 3XSTOP transcriptional/translational termination sequence and a single frt site (remaining after excision of a selection cassette from Nrastm1Nesh by FLP recombinase). A single point mutation in exon 2 has replaced a nucleotide triplet encoding glutamine at amino acid position 61 with an arginine codon (Q61R); this represents the predominant NRAS mutation observed in human melanomas. (J:220627)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
