Nras^tm1.1Nesh

The 5' untranslated region (5'-UTR) of the gene is interrupted 1,046 base pairs downstream of the transcription start site by a splice acceptor followed by a 3XSTOP transcriptional/translational termination sequence and a single frt site (remaining after excision of a selection cassette from Nrastm1Nesh by FLP recombinase). A single point mutation in exon 2 has replaced a nucleotide triplet encoding glutamine at amino acid position 61 with an arginine codon (Q61R); this represents the predominant NRAS mutation observed in human melanomas. (J:220627)