A conditional-ready gene trap cassette with F3, Frt, LoxP, and Lox511 sites flanking a beta-geo reporter was inserted into exon 1 and subsequent Cre- and Flp-mediated excision yielded this allele in which the inverted insertion was re-inverted to the forward orientation on the positive strand so transcription is disrupted resulting in the final null allele configuration. (J:236978)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Gene trapped
Insertion of gene trap vector
--
1
6
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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