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This transgene consists of the rat prion promoter, lacZ reporter gene, and 500 ATTCT repeats of human ATXN10 (isolated from a Mexican patient with ataxia and epilepsy) inserted in the 3' UTR of lacZ. RT-PCR analysis shows that the transgene is widely expressed in the central nervous system, with highest expression in the hippocampus, and also in the heart, liver, muscle, and skin. Three founders (1,2, 3) were established, however the pound symbol (#) is used when line is not specified and/or lines are pooled. (J:222081)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
