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A Flag-HA-Shox2a-DsRed-polyA cassette and an FRT flanked neo cassette were inserted at the start site in exon 1 via homologous recombination. Flp mediated recombination removed the neo cassette. The Shox2a cDNA encodes an N-terminal FLAG-HA- tagged full length Shox2 gene. The Shox2a cDNA has a heterologous 3'UTR releasing the gene from endogenous miRNA control. Immunofluorescence analysis indicates aberrant elevated expression of the mutant protein at E16.5 in the atrial septum. (J:212095)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
