The targeting cassette inserted into exon 1 upstream of the translation start site a rabbit HBB2 splice donor, intron and splice acceptor; an inducible improved cre fused to two modified Esr1 binding domains (icre/Esr1*); and an FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. (J:219867)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count