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This transgene expresses a dominant negative mutated form of Ppp3ca under the control of the Lck proximal promoter. Sequence encoding five amino acid residues in the phosphatase active site (148-52) was deleted. Three transgenic lines were established. Line 28 expresses 50 copies of the transgene. (J:62700)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
