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The murine Mbp promoter drives the expression of human alpha-synuclein cDNA (nucleotides 53-475). Line 29 is the highest expressor, followed by lines 1, 2, and 31. Highest mRNA expression is seen in the corpus callosum, followed by white matter tracts in the brainstem, spinal cord, basal ganglia, and cerebellum and lowest levels in the hippocampus, neocortex, and cortical layers in the cerebellum. Immunohistochemical analysis indicates protein expression in glial but not neuroal cells of the neocortex, basal ganglia, corpus callosum and cerebellum. Four lines were generated; 1, 2, 29, and 31. (J:102867)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
