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EN
The coding sequence was replaced with a cDNA with a G to A point mutation that results in an amino acid substitution of lysine for glutamic acid at position 359 (E359K). Cre-mediated recombination removed a floxed neomycin resistance cassette inserted upstream of the modified cDNA. Western blot analysis revealed a similar expression of FEN1 in wild-type and homozygous mutant mice. (J:218627)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
