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The targeting construct replaced exon 4 with an EGFP, inducible cre recombinase fusion gene (EGFP/cre/ERT2) and an FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. The EGFP could not be detected by direct fluorescence or anti-GFP antibody staining. Expression of the EGFP/cre/ERT2 fusion protein is detected by anti-estrogen receptor antibody staining in adult retinal neurons. (J:214080)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
