The targeting vector contains a loxP site 290 bp upstream of exon 4 and loxP site followed by a FRT-flanked PGK-Neo selection cassette 380 bp downstream of exon 4. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 4 floxed. (J:219327)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count