A targeting vector was designed to insert a loxP site followed by a FRT-flanked neomycin resistance (neo) cassette upstream of exon 1, and a second loxP site downstream of exon 1. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 1 floxed. (J:204710)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count