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An A to G nucleotide change was introduced in codon 300 of exon 9. This caused a Threonine to Alaninee mutation. An FRT flanked neomycin resistance was also inserted downstream of exon 9. Subsequent flp recombinase expression excised the selection cassette. This mutation reduces the stability of the protein resulting in reduced steady state levels. (J:211028)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
