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The following were inserted, in order, between the promoter and coding sequences of the endogenous gene: tTA-pA-STOP-"PF" [TetO-tTA] cassette-pA-loxP-Neo-loxP. The PF (positive feedback) amplification cassette enhances tTA expression following the removal of the STOP. Cre-mediated recombination removed the downstream floxed neo cassette. Transgene expression is eight-fold higher than endogenous alpha-synuclein expression in dopaminergic neurons. (J:218892)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
