The endogenous locus was targeted with two rounds of homologous recombination that inserted a floxed neomycin selection cassette into intron 1 and a cassette containing a floxed puromycin resistance gene followed by the lacZ reporter gene fused to a nuclear localization signal (nls-lacZ) into the 3' untranslated region. Exons 2 through 9 were flanked by the floxed selection genes. (J:210236)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count