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EN
Mutations (V745L, M761Aand S828A) were introduced into the ATP-binding pocket of the kinase to create an analog sensitive kinase allele and a floxed neo cassette was inserted in intron 17 via homologous recombination. Cre mediated recombination removed the neo cassette. Kinase activity of this allele can be controlled by the administration of 1Na-PP1, a derivative of the general kinase inhibitor PP1. (J:210627)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
