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Exons 3-5, encoding the Toll-IL-1 receptor (TIR) domain, were flanked by loxP sites. The frt-flanked neomycin resistance cassette was removed via flp-mediated recombination. When the floxed region is removed via cre-mediated recombination, splicing from exon 2 to exon 6 results in a frameshift mutation. (J:209373)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
