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Using a modified BAC RP24-359N5 for homologous recombination, a C723 modification in exon 15 was made via site-directed mutagenesis using an FRT-flanked neo and arabinose-induced FLP, which left behind one FRT site, and a loxP-flanked Stop-neo cassette was additionally inserted into intron 1, which resulted in this constitutively expressed null allele that can be cre-excised to yield an expressed C723A mutant allele. (J:216802)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
