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The targeting construct introduced nucleotide substitutions in exons 15 and 17 that result in the amino acid substitutions of glutamic acid for arginine and lysine at positions 461 and 542, respectively (R461E, K542E). These mutations disrupt interaction with the transactivation domain of E2f1. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted upstream of exon 17. (J:215358)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
