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The construct is designed with the CMV-IE enhancer/chicken beta-actin hybrid promoter (CAG; from the pCAGGS vector), a loxP-flanked transcriptional STOP cassette (containing beta galactosidase and a polyadenylation signal), and the soluble form of the murine urokinase-type plasminogen activator receptor (Plaur) gene. The soluble form of Plaur (suPAR) encodes a 60 kDa truncated protein, lacking the glycophosphatidylinositol (GPI) anchored three domain (commonly referred to as D1, D2, D3) protein. (J:217443)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
