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The targeting construct inserted into the locus a CAG promoter, floxed membrane-targeted tandem-dimer Tomato (mT) reporter gene, an improved sensor cGMP indicator (cGi500; containing an FRET-activated, cGMP-sensitive ECFP/EYFP fusion) and an FRT-flanked neomycin resistance cassette. Cre-mediated recombination removed the Tomato reporter gene permanently activating the cGMP sensor allele so that the cGMP sensor is expressed ubiquitously. The cGMP indicator has an EC50 of 500 nmol/L. (J:213388)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
