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Using BAC recombineering roughly 3 Mbp of the mouse locus including all of the Vh Dh and Jh gene segments was replaced with 940 kb of contiguous human sequence containing the equivalent human gene segments. The proximal junction of the replacement was placed about 200 bp downstream from the last J segment and the distal junction was placed several hundred bp upstream of the most 5' V segment of the human gene and about 9 kbp downstream from J558.55. Flp-mediated recombination removed the selection cassette. (J:208619)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
