A loxP site was inserted in intron 13 and an FRT flanked neomycin selection cassette followed by a second loxP was inserted in intron 20. After successful targeting the selection cassette was excised by transient expression of flp recombinase. (J:216722)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count