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An FRT-flanked PGK-neomycin cassette and loxP site were introduced to intron 3 and a loxP site was placed in intron 4 via homologous recombination. The neomycin cassette was excised from resultant mice through crosses with a Flp recombinase-expressing strain, leaving exon 4 flanked by loxP sites. Cre-mediated recombination removed exon 4. Immunoblot confirms the absence of protein. (J:207976)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
