Using a BAC-based targeting approach, a loxP-splice acceptor (SA) site was introduced to intron 1 of the Fas gene and an FRT-PGK-Neo-FRT-loxP-SA-human placental alkaline phosphatase (PLAP)-pA was placed in intron 9. Flp-mediated recombination removed the neomycin cassette. (J:101977)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count