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Mitochondria with a ChrM:7731G>A mutation in the mitochondrially encoded lysine tRNA were identified in P29 cells. Cybrids created in B82 cells lacking mitochondrial DNA and then transferred to TT2-F ES cells were introduced into 8-cell stage embryos of ICR mice. Cybrids were estimated to have 70% mutant DNA. (J:206827)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
