A loxP-flanked neomycin selection cassette was 3' to exon 3 and a sigle loxP site was inserted 5' to exon 5. Cre-mediated recombination in ES cells resulted in the deletion of the selection cassette and exons 3-5. (J:210814)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count