A loxP site and a neo-tk cassette flanked by loxP sites were inserted into the MscI site of the 5' untranslated region and NheI site within the first intron, respectively. The loxP flanked neo-tk cassette was removed via Cre-mediated recombination, leaving the first coding exon flanked by loxP sites. (J:214945)
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cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count