A targeting vector was designed to insert a loxP site upstream of exon 6, and a FRT-flanked neomycin resistance (neo) cassette followed by a single loxP site downstream of exon 7 of the gene. Flp mediated recombination removed the neomycin cassette. (J:213840)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count